Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GNB4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNB4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNB4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:179,260,956–179,261,810 | 190.0 kb | Distal (>10kb) Multiome | 616 | |
| chr3:179,322,380–179,323,876 | 128.5 kb | Distal (>10kb) Multiome | 958 | |
| chr3:179,346,338–179,348,224 | 103.8 kb | Distal (>10kb) Multiome | 843 | |
| chr3:179,450,888–179,452,034 | 42 bp | At TSS Multiome | 580 | |
| chr3:179,504,159–179,505,204 | 53.1 kb | Distal (>10kb) Multiome | 128 | |
| chr3:179,526,783–179,527,418 | 75.6 kb | Distal (>10kb) Multiome HiCAR | 358 | |
| chr3:179,562,395–179,564,138 | 111.4 kb | Distal (>10kb) Multiome | 866 | |
| chr3:179,604,200–179,605,304 | 153.3 kb | Distal (>10kb) Multiome | 786 | |
| chr3:179,608,248–179,609,637 | 157.4 kb | Distal (>10kb) Multiome | 176 | |
| chr3:179,652,424–179,653,975 | 201.6 kb | Distal (>10kb) Multiome | 805 |
Genomic view of the GNB4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.