This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for GLRX3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLRX3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLRX3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:128,209,992–128,211,458 | 1926.0 kb | Distal (>10kb) Multiome HiCAR | 389 | |
| chr10:129,889,031–129,889,634 | 247.1 kb | Distal (>10kb) Multiome | 197 | |
| chr10:129,958,664–129,960,120 | 177.1 kb | Distal (>10kb) Multiome | 209 | |
| chr10:129,962,882–129,965,582 | 172.0 kb | Distal (>10kb) Multiome | 391 | |
| chr10:129,966,749–129,967,839 | 169.2 kb | Distal (>10kb) Multiome | 84 | |
| chr10:129,967,889–129,969,505 | 167.3 kb | Distal (>10kb) Multiome | 258 | |
| chr10:129,971,147–129,971,990 | 164.7 kb | Distal (>10kb) Multiome | 290 | |
| chr10:129,985,548–129,985,944 | 150.6 kb | Distal (>10kb) Multiome | 16 | |
| chr10:130,105,630–130,106,130 | 30.5 kb | Distal (>10kb) Multiome | 94 | |
| chr10:130,109,641–130,111,870 | 25.6 kb | Distal (>10kb) Multiome | 1015 | |
| chr10:130,127,662–130,128,099 | 8.3 kb | Proximal (<10kb) | 267 | |
| chr10:130,135,986–130,137,502 | 11 bp | At TSS Multiome | 783 | |
| chr10:130,189,597–130,191,106 | 54.0 kb | Distal (>10kb) Multiome | 709 |
Genomic view of the GLRX3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.