Predicted to be involved in spermatogenesis. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of cell population proliferation; and negative regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for GGNBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GGNBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GGNBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:36,482,565–36,483,505 | 61.9 kb | Distal (>10kb) Multiome | 734 | |
| chr17:36,486,066–36,487,171 | 58.3 kb | Distal (>10kb) Multiome | 719 | |
| chr17:36,534,162–36,535,815 | 9.7 kb | Proximal (<10kb) Multiome | 1014 | |
| chr17:36,544,068–36,546,005 | 535 bp | At TSS Multiome | 968 | |
| chr17:36,591,430–36,592,642 | 46.9 kb | Distal (>10kb) Multiome | 585 | |
| chr17:36,600,997–36,602,715 | 56.6 kb | Distal (>10kb) Multiome | 823 | |
| chr17:36,612,842–36,614,639 | 68.5 kb | Distal (>10kb) Multiome | 111 | |
| chr17:36,657,825–36,658,420 | 113.1 kb | Distal (>10kb) Multiome | 220 | |
| chr17:36,722,258–36,722,869 | 177.5 kb | Distal (>10kb) Multiome | 428 | |
| chr17:36,727,484–36,729,207 | 183.4 kb | Distal (>10kb) Multiome | 373 | |
| chr17:36,742,321–36,742,786 | 197.6 kb | Distal (>10kb) Multiome | 38 | |
| chr17:36,808,179–36,808,595 | 263.4 kb | Distal (>10kb) Multiome | 138 |
Genomic view of the GGNBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.