Enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Involved in UDP-N-acetylglucosamine biosynthetic process and fructose 6-phosphate metabolic process. Predicted to be located in cytosol. Implicated in type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GFPT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GFPT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GFPT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:180,059,605–180,060,144 | 293.6 kb | Distal (>10kb) Multiome | 18 | |
| chr5:180,069,680–180,070,372 | 283.4 kb | Distal (>10kb) Multiome | 240 | |
| chr5:180,071,104–180,072,473 | 281.4 kb | Distal (>10kb) Multiome | 1084 | |
| chr5:180,090,117–180,091,054 | 262.9 kb | Distal (>10kb) Multiome | 575 | |
| chr5:180,208,671–180,209,518 | 144.2 kb | Distal (>10kb) Multiome | 385 | |
| chr5:180,291,390–180,292,854 | 61.3 kb | Distal (>10kb) Multiome | 694 | |
| chr5:180,292,972–180,293,953 | 59.7 kb | Distal (>10kb) Multiome | 556 | |
| chr5:180,350,789–180,351,026 | 2.3 kb | Proximal (<10kb) | 23 | |
| chr5:180,352,255–180,354,009 | 134 bp | At TSS Multiome | 450 | |
| chr5:180,493,929–180,495,203 | 141.0 kb | Distal (>10kb) Multiome | 803 | |
| chr5:180,618,726–180,619,463 | 265.8 kb | Distal (>10kb) Multiome | 289 | |
| chr5:180,648,868–180,649,861 | 295.9 kb | Distal (>10kb) Multiome | 281 |
Genomic view of the GFPT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.