Transcription factors with Perturb-seq knockdown data for GATA3-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GATA3-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GATA3-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:8,043,070–8,044,042 | 9.4 kb | Proximal (<10kb) | 183 | |
| chr10:8,044,436–8,045,614 | 7.9 kb | Proximal (<10kb) | 246 | |
| chr10:8,046,840–8,047,373 | 6.1 kb | Proximal (<10kb) | 84 | |
| chr10:8,047,568–8,048,598 | 4.9 kb | Proximal (<10kb) | 190 | |
| chr10:8,049,343–8,052,545 | 938 bp | At TSS | 796 | |
| chr10:8,053,150–8,055,390 | at TSS | At TSS | 590 | |
| chr10:8,055,536–8,056,709 | 2.1 kb | Proximal (<10kb) | 272 | |
| chr10:8,057,550–8,057,976 | 4.1 kb | Proximal (<10kb) | 92 | |
| chr10:8,058,367–8,058,884 | 4.9 kb | Proximal (<10kb) | 115 | |
| chr10:8,061,155–8,061,606 | 7.7 kb | Proximal (<10kb) | 120 |
Genomic view of the GATA3-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.