This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for GARS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GARS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GARS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:30,472,499–30,473,444 | 121.9 kb | Distal (>10kb) Multiome | 123 | |
| chr7:30,478,426–30,479,128 | 116.2 kb | Distal (>10kb) Multiome | 756 | |
| chr7:30,504,202–30,505,455 | 89.9 kb | Distal (>10kb) Multiome | 824 | |
| chr7:30,544,196–30,544,698 | 50.3 kb | Distal (>10kb) Multiome | 40 | |
| chr7:30,594,119–30,595,511 | 46 bp | At TSS Multiome | 1016 | |
| chr7:30,681,420–30,682,927 | 87.7 kb | Distal (>10kb) Multiome | 319 | |
| chr7:30,699,970–30,700,584 | 105.5 kb | Distal (>10kb) Multiome | 149 | |
| chr7:30,771,029–30,771,985 | 176.7 kb | Distal (>10kb) Multiome | 536 |
Genomic view of the GARS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.