This gene encodes an N-acetylgalactosaminyltransferase. This gene is located centromeric to the common deleted region in Williams-Beuren syndrome (WBS), a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. This protein may play a role in membrane trafficking. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for GALNT17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GALNT17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GALNT17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:70,951,381–70,951,908 | 180.5 kb | Distal (>10kb) Multiome | 26 | |
| chr7:71,131,203–71,132,732 | 528 bp | At TSS Multiome | 246 | |
| chr7:71,286,808–71,287,626 | 155.2 kb | Distal (>10kb) Multiome HiCAR | 76 | |
| chr7:71,389,773–71,391,036 | 258.1 kb | Distal (>10kb) Multiome | 94 | |
| chr7:71,402,663–71,403,466 | 270.8 kb | Distal (>10kb) Multiome HiCAR | 53 | |
| chr7:71,456,696–71,459,082 | 325.0 kb | Distal (>10kb) Multiome HiCAR | 114 | |
| chr7:71,733,066–71,733,625 | 601.2 kb | Distal (>10kb) Multiome HiCAR | 371 | |
| chr7:71,752,105–71,752,600 | 620.2 kb | Distal (>10kb) Multiome HiCAR | 296 |
Genomic view of the GALNT17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.