Transcription factors with Perturb-seq knockdown data for GABPB1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GABPB1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GABPB1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:50,181,930–50,183,387 | 172.8 kb | Distal (>10kb) Multiome | 703 | |
| chr15:50,353,896–50,355,794 | 16 bp | At TSS Multiome | 1140 | |
| chr15:50,358,933–50,359,117 | 3.7 kb | Proximal (<10kb) | 123 | |
| chr15:50,423,700–50,424,834 | 69.1 kb | Distal (>10kb) Multiome | 874 | |
| chr15:50,466,510–50,467,099 | 111.5 kb | Distal (>10kb) Multiome | 48 |
Genomic view of the GABPB1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.