This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for GAB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:78,139,106–78,140,207 | 278.1 kb | Distal (>10kb) Multiome | 842 | |
| chr11:78,187,536–78,189,464 | 229.2 kb | Distal (>10kb) Multiome | 905 | |
| chr11:78,365,205–78,365,789 | 52.4 kb | Distal (>10kb) Multiome | 332 | |
| chr11:78,416,378–78,418,582 | 128 bp | At TSS Multiome | 924 | |
| chr11:78,494,782–78,495,377 | 77.3 kb | Distal (>10kb) Multiome | 21 | |
| chr11:78,574,373–78,575,502 | 157.1 kb | Distal (>10kb) Multiome HiCAR | 823 | |
| chr11:78,592,666–78,593,517 | 175.3 kb | Distal (>10kb) Multiome | 156 | |
| chr11:78,645,133–78,645,701 | 227.5 kb | Distal (>10kb) Multiome | 200 |
Genomic view of the GAB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.