Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in apoptotic process and protein ubiquitination. Predicted to act upstream of or within blastocyst development; negative regulation of intrinsic apoptotic signaling pathway; and protein polyubiquitination. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for G2E3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = G2E3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of G2E3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:28,758,498–28,760,371 | 1799.8 kb | Distal (>10kb) Multiome HiCAR | 232 | |
| chr14:30,270,315–30,271,183 | 288.3 kb | Distal (>10kb) Multiome | 415 | |
| chr14:30,558,663–30,560,074 | 65 bp | At TSS Multiome | 1016 | |
| chr14:30,562,367–30,562,597 | 3.2 kb | Proximal (<10kb) | 48 | |
| chr14:30,621,361–30,622,870 | 63.2 kb | Distal (>10kb) Multiome | 1061 | |
| chr14:30,822,055–30,822,752 | 263.1 kb | Distal (>10kb) Multiome | 275 |
Genomic view of the G2E3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.