FXR2
FMR1 autosomal homolog 2 | FMR1L2

The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome. [provided by RefSeq, Jul 2008]

Member of: DE-4 DE-4.20 Developmental clusters: GC6
Biological processes 36 terms
RNA binding (GO:0003723)RNA binding (GO:0003723)RNA binding (GO:0003723)animal organ development (GO:0048513)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic ribonucleoprotein granule (GO:0036464)cytoplasmic stress granule (GO:0010494)cytoplasmic stress granule (GO:0010494)cytoplasmic stress granule (GO:0010494)cytosol (GO:0005829)dentate gyrus development (GO:0021542)identical protein binding (GO:0042802)mRNA 3'-UTR binding (GO:0003730)mRNA binding (GO:0003729)mRNA destabilization (GO:0061157)mRNA transport (GO:0051028)membrane (GO:0016020)neuron projection (GO:0043005)nucleic acid binding (GO:0003676)nucleus (GO:0005634)positive regulation of long-term neuronal synaptic plasticity (GO:0048170)positive regulation of translation (GO:0045727)postsynapse (GO:0098794)presynapse (GO:0098793)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)regulation of mRNA metabolic process (GO:1903311)regulation of mRNA stability (GO:0043488)regulation of translation (GO:0006417)regulation of translation at presynapse, modulating synaptic transmission (GO:0099577)translation regulator activity (GO:0045182)
Expression (TPM)
FXR2 — as a Regulated Gene

TFs regulating FXR2 0 TFs

Transcription factors with Perturb-seq knockdown data for FXR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FXR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to FXR2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FXR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:7,314,722–7,315,725 299.6 kb Distal (>10kb) Multiome 843
chr17:7,328,881–7,330,972 285.4 kb Distal (>10kb) Multiome 809
chr17:7,349,378–7,350,590 264.6 kb Distal (>10kb) Multiome 414
chr17:7,351,208–7,352,575 262.8 kb Distal (>10kb) Multiome 857
chr17:7,356,082–7,356,523 258.6 kb Distal (>10kb) Multiome 485
chr17:7,383,791–7,384,537 230.7 kb Distal (>10kb) Multiome 218
chr17:7,393,924–7,395,223 220.2 kb Distal (>10kb) Multiome 744
chr17:7,403,290–7,405,695 210.6 kb Distal (>10kb) Multiome 838
chr17:7,435,167–7,437,681 177.8 kb Distal (>10kb) Multiome 828
chr17:7,437,892–7,438,555 176.6 kb Distal (>10kb) Multiome 224
chr17:7,440,048–7,441,211 174.2 kb Distal (>10kb) Multiome 487
chr17:7,444,968–7,446,142 169.3 kb Distal (>10kb) Multiome 632
chr17:7,455,450–7,456,019 159.2 kb Distal (>10kb) Multiome 414
chr17:7,478,839–7,480,126 135.4 kb Distal (>10kb) Multiome 574
chr17:7,483,139–7,485,576 130.4 kb Distal (>10kb) Multiome 1156
chr17:7,548,693–7,549,285 65.9 kb Distal (>10kb) Multiome 387
chr17:7,560,249–7,562,536 53.0 kb Distal (>10kb) Multiome 759
chr17:7,572,039–7,574,418 41.0 kb Distal (>10kb) Multiome 1071
chr17:7,579,018–7,579,876 35.4 kb Distal (>10kb) Multiome 844
chr17:7,583,063–7,584,547 31.1 kb Distal (>10kb) Multiome 921
chr17:7,588,871–7,590,534 24.7 kb Distal (>10kb) Multiome 319
chr17:7,614,065–7,615,780 210 bp At TSS Multiome 708
chr17:7,627,090–7,628,247 12.9 kb Distal (>10kb) Multiome 712
chr17:7,650,010–7,652,127 35.9 kb Distal (>10kb) Multiome 467
chr17:7,685,876–7,686,907 71.4 kb Distal (>10kb) Multiome 765
chr17:7,687,214–7,687,777 72.6 kb Distal (>10kb) Multiome 710
chr17:7,687,867–7,688,863 73.4 kb Distal (>10kb) Multiome 700
chr17:7,703,383–7,703,975 88.8 kb Distal (>10kb) Multiome 141
chr17:7,704,799–7,705,590 90.2 kb Distal (>10kb) Multiome 325
chr17:7,716,832–7,717,983 102.5 kb Distal (>10kb) Multiome 759
chr17:7,833,417–7,837,960 220.7 kb Distal (>10kb) Multiome 1160
chr17:7,841,438–7,843,228 227.3 kb Distal (>10kb) Multiome 861
chr17:7,843,355–7,844,130 228.7 kb Distal (>10kb) Multiome 614
chr17:7,844,349–7,845,186 230.0 kb Distal (>10kb) Multiome 617
chr17:7,851,538–7,852,239 237.0 kb Distal (>10kb) Multiome 531
chr17:7,856,600–7,858,747 242.6 kb Distal (>10kb) Multiome 942
chr17:7,885,205–7,885,734 270.4 kb Distal (>10kb) Multiome 371
chr17:7,887,616–7,888,198 272.9 kb Distal (>10kb) Multiome 581

Genome Browser

Genomic view of the FXR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:7,304,722 – 7,898,198
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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