This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for FUT8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FUT8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FUT8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:65,187,313–65,188,086 | 225.1 kb | Distal (>10kb) Multiome | 124 | |
| chr14:65,212,664–65,213,594 | 199.5 kb | Distal (>10kb) Multiome HiCAR | 50 | |
| chr14:65,226,838–65,227,673 | 185.5 kb | Distal (>10kb) Multiome HiCAR | 588 | |
| chr14:65,255,144–65,256,610 | 157.0 kb | Distal (>10kb) Multiome HiCAR | 499 | |
| chr14:65,281,802–65,282,455 | 130.5 kb | Distal (>10kb) Multiome | 179 | |
| chr14:65,334,489–65,335,389 | 77.8 kb | Distal (>10kb) Multiome | 283 | |
| chr14:65,411,641–65,414,012 | 1.0 kb | Proximal (<10kb) Multiome | 976 | |
| chr14:65,813,612–65,814,373 | 401.3 kb | Distal (>10kb) Multiome HiCAR | 105 | |
| chr14:65,828,014–65,828,746 | 415.8 kb | Distal (>10kb) Multiome HiCAR | 160 |
Genomic view of the FUT8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.