This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FSTL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FSTL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FSTL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:120,284,858–120,285,627 | 165.7 kb | Distal (>10kb) Multiome | 237 | |
| chr3:120,348,500–120,350,077 | 101.8 kb | Distal (>10kb) Multiome | 1003 | |
| chr3:120,416,932–120,417,959 | 33.6 kb | Distal (>10kb) Multiome | 482 | |
| chr3:120,448,565–120,449,205 | 1.8 kb | Proximal (<10kb) | 163 | |
| chr3:120,450,045–120,452,154 | 41 bp | At TSS Multiome | 496 | |
| chr3:120,558,699–120,560,290 | 108.1 kb | Distal (>10kb) Multiome HiCAR | 654 | |
| chr3:120,595,704–120,596,910 | 145.3 kb | Distal (>10kb) Multiome | 683 | |
| chr3:120,604,594–120,605,753 | 154.2 kb | Distal (>10kb) Multiome | 62 | |
| chr3:120,622,775–120,623,611 | 172.1 kb | Distal (>10kb) Multiome | 221 | |
| chr3:120,677,217–120,678,016 | 226.4 kb | Distal (>10kb) Multiome | 75 | |
| chr3:120,719,201–120,720,128 | 268.6 kb | Distal (>10kb) Multiome | 147 | |
| chr3:120,741,971–120,743,234 | 291.6 kb | Distal (>10kb) Multiome | 788 |
Genomic view of the FSTL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.