Enables transcription coactivator binding activity and transcription corepressor activity. Involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and pericentric heterochromatin. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FLYWCH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLYWCH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLYWCH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:2,673,059–2,673,910 | 238.5 kb | Distal (>10kb) Multiome | 471 | |
| chr16:2,682,205–2,683,006 | 229.5 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:2,720,741–2,721,896 | 190.7 kb | Distal (>10kb) Multiome | 758 | |
| chr16:2,751,637–2,753,398 | 159.5 kb | Distal (>10kb) Multiome | 1074 | |
| chr16:2,776,766–2,778,256 | 134.7 kb | Distal (>10kb) Multiome HiCAR | 828 | |
| chr16:2,867,958–2,868,665 | 43.6 kb | Distal (>10kb) Multiome | 960 | |
| chr16:2,882,042–2,883,813 | 29.1 kb | Distal (>10kb) Multiome | 838 | |
| chr16:2,904,002–2,906,321 | 7.7 kb | Proximal (<10kb) Multiome | 994 | |
| chr16:2,911,480–2,912,624 | 124 bp | At TSS Multiome | 784 | |
| chr16:2,963,159–2,965,475 | 52.0 kb | Distal (>10kb) Multiome | 628 | |
| chr16:2,968,641–2,970,561 | 57.2 kb | Distal (>10kb) Multiome | 1039 | |
| chr16:2,979,651–2,981,140 | 68.5 kb | Distal (>10kb) Multiome | 795 | |
| chr16:2,981,390–2,982,257 | 69.8 kb | Distal (>10kb) Multiome | 460 | |
| chr16:3,003,612–3,004,589 | 92.0 kb | Distal (>10kb) Multiome | 652 | |
| chr16:3,007,583–3,008,956 | 96.5 kb | Distal (>10kb) Multiome | 514 | |
| chr16:3,009,722–3,010,376 | 98.1 kb | Distal (>10kb) Multiome | 395 | |
| chr16:3,017,242–3,018,799 | 106.2 kb | Distal (>10kb) Multiome | 451 | |
| chr16:3,019,969–3,022,268 | 108.3 kb | Distal (>10kb) Multiome | 963 | |
| chr16:3,022,890–3,024,532 | 112.2 kb | Distal (>10kb) Multiome | 933 | |
| chr16:3,027,854–3,029,038 | 116.3 kb | Distal (>10kb) Multiome | 546 | |
| chr16:3,036,222–3,037,148 | 124.9 kb | Distal (>10kb) Multiome | 256 | |
| chr16:3,045,413–3,047,408 | 134.2 kb | Distal (>10kb) Multiome | 510 | |
| chr16:3,058,226–3,060,102 | 147.4 kb | Distal (>10kb) Multiome | 769 | |
| chr16:3,098,550–3,100,475 | 188.3 kb | Distal (>10kb) Multiome | 454 | |
| chr16:3,106,146–3,106,906 | 194.6 kb | Distal (>10kb) Multiome | 851 | |
| chr16:3,123,818–3,124,940 | 212.4 kb | Distal (>10kb) Multiome | 800 | |
| chr16:3,134,425–3,135,445 | 223.0 kb | Distal (>10kb) Multiome | 752 | |
| chr16:3,149,357–3,151,137 | 238.6 kb | Distal (>10kb) Multiome | 975 | |
| chr16:3,152,009–3,153,129 | 240.8 kb | Distal (>10kb) Multiome | 889 | |
| chr16:3,156,990–3,157,742 | 245.4 kb | Distal (>10kb) Multiome | 680 | |
| chr16:3,158,260–3,159,345 | 246.8 kb | Distal (>10kb) Multiome | 764 | |
| chr16:3,171,474–3,172,591 | 260.1 kb | Distal (>10kb) Multiome | 574 | |
| chr16:3,174,125–3,174,566 | 262.3 kb | Distal (>10kb) Multiome | 371 | |
| chr16:3,175,429–3,175,953 | 263.7 kb | Distal (>10kb) Multiome | 483 | |
| chr16:3,182,514–3,183,488 | 270.8 kb | Distal (>10kb) Multiome | 690 | |
| chr16:3,187,874–3,189,822 | 277.5 kb | Distal (>10kb) Multiome | 679 | |
| chr16:3,191,282–3,192,194 | 279.7 kb | Distal (>10kb) Multiome | 509 |
Genomic view of the FLYWCH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.