FLT1
fms related receptor tyrosine kinase 1 | VEGFR1, FLT

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

Developmental clusters: GC4
Biological processes 58 terms
ATP binding (GO:0005524)blood vessel morphogenesis (GO:0048514)cell migration (GO:0016477)cell migration (GO:0016477)cell surface receptor protein tyrosine kinase signaling pathway (GO:0007169)cell surface receptor protein tyrosine kinase signaling pathway (GO:0007169)cellular response to vascular endothelial growth factor stimulus (GO:0035924)cytoplasm (GO:0005737)embryonic morphogenesis (GO:0048598)endosome (GO:0005768)extracellular region (GO:0005576)extracellular region (GO:0005576)focal adhesion (GO:0005925)growth factor binding (GO:0019838)growth factor binding (GO:0019838)growth factor binding (GO:0019838)hyaloid vascular plexus regression (GO:1990384)monocyte chemotaxis (GO:0002548)negative regulation of vascular endothelial cell proliferation (GO:1905563)peptidyl-tyrosine phosphorylation (GO:0018108)placental growth factor receptor activity (GO:0036332)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of MAP kinase activity (GO:0043406)positive regulation of MAPK cascade (GO:0043410)positive regulation of MAPK cascade (GO:0043410)positive regulation of MAPK cascade (GO:0043410)positive regulation of angiogenesis (GO:0045766)positive regulation of cell migration (GO:0030335)positive regulation of cell migration (GO:0030335)positive regulation of cell migration (GO:0030335)positive regulation of cell population proliferation (GO:0008284)positive regulation of cell population proliferation (GO:0008284)positive regulation of developmental process (GO:0051094)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)protein autophosphorylation (GO:0046777)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein tyrosine kinase activity (GO:0004713)regulation of cell population proliferation (GO:0042127)signaling receptor complex (GO:0043235)signaling receptor complex (GO:0043235)sprouting angiogenesis (GO:0002040)transmembrane receptor protein tyrosine kinase activity (GO:0004714)transmembrane receptor protein tyrosine kinase activity (GO:0004714)vascular endothelial growth factor receptor activity (GO:0005021)vascular endothelial growth factor receptor activity (GO:0005021)vascular endothelial growth factor receptor activity (GO:0005021)vascular endothelial growth factor receptor activity (GO:0005021)vascular endothelial growth factor receptor activity (GO:0005021)vascular endothelial growth factor receptor signaling pathway (GO:0048010)vascular endothelial growth factor receptor signaling pathway (GO:0048010)vascular endothelial growth factor receptor signaling pathway (GO:0048010)vascular endothelial growth factor receptor signaling pathway (GO:0048010)vascular endothelial growth factor receptor-1 signaling pathway (GO:0036323)vascular endothelial growth factor signaling pathway (GO:0038084)
Expression (TPM)
FLT1 — as a Regulated Gene

TFs regulating FLT1 0 TFs

Transcription factors with Perturb-seq knockdown data for FLT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to FLT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr13:28,429,691–28,430,157 65.1 kb Distal (>10kb) Multiome 217
chr13:28,438,646–28,439,159 56.2 kb Distal (>10kb) Multiome 55
chr13:28,493,679–28,495,839 132 bp At TSS Multiome 388
chr13:28,530,994–28,531,548 36.1 kb Distal (>10kb) Multiome 200
chr13:28,532,198–28,533,247 37.7 kb Distal (>10kb) Multiome 397
chr13:28,545,399–28,546,237 50.8 kb Distal (>10kb) Multiome 265
chr13:28,658,912–28,659,587 164.0 kb Distal (>10kb) Multiome 797
chr13:28,684,201–28,684,881 189.4 kb Distal (>10kb) Multiome 106
chr13:28,704,351–28,704,874 209.4 kb Distal (>10kb) Multiome 44
chr13:28,716,279–28,716,910 221.5 kb Distal (>10kb) Multiome 277
chr13:28,718,504–28,719,560 223.9 kb Distal (>10kb) Multiome 517

Genome Browser

Genomic view of the FLT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr13:28,419,691 – 28,729,560
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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