Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FLOT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLOT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLOT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:28,598,491–28,599,842 | 298.5 kb | Distal (>10kb) Multiome | 810 | |
| chr17:28,621,936–28,622,562 | 275.3 kb | Distal (>10kb) Multiome | 55 | |
| chr17:28,644,541–28,645,596 | 252.4 kb | Distal (>10kb) Multiome | 795 | |
| chr17:28,661,635–28,662,527 | 235.5 kb | Distal (>10kb) Multiome | 809 | |
| chr17:28,710,720–28,712,813 | 186.2 kb | Distal (>10kb) Multiome | 892 | |
| chr17:28,717,030–28,718,784 | 179.8 kb | Distal (>10kb) Multiome | 492 | |
| chr17:28,718,918–28,720,313 | 177.9 kb | Distal (>10kb) Multiome | 927 | |
| chr17:28,724,652–28,729,474 | 170.6 kb | Distal (>10kb) Multiome | 1286 | |
| chr17:28,743,083–28,744,926 | 153.6 kb | Distal (>10kb) Multiome HiCAR | 991 | |
| chr17:28,745,076–28,746,436 | 152.0 kb | Distal (>10kb) Multiome HiCAR | 568 | |
| chr17:28,749,859–28,750,549 | 147.4 kb | Distal (>10kb) Multiome HiCAR | 550 | |
| chr17:28,811,615–28,812,945 | 85.1 kb | Distal (>10kb) Multiome | 699 | |
| chr17:28,842,307–28,843,098 | 54.9 kb | Distal (>10kb) Multiome | 717 | |
| chr17:28,854,460–28,855,289 | 42.7 kb | Distal (>10kb) Multiome | 780 | |
| chr17:28,896,962–28,898,028 | 55 bp | At TSS Multiome | 846 | |
| chr17:28,902,302–28,903,488 | 5.4 kb | Proximal (<10kb) Multiome | 967 | |
| chr17:28,950,281–28,952,708 | 54.0 kb | Distal (>10kb) Multiome | 989 | |
| chr17:28,984,463–28,984,954 | 87.0 kb | Distal (>10kb) Multiome | 33 | |
| chr17:28,985,971–28,986,457 | 88.6 kb | Distal (>10kb) Multiome | 123 | |
| chr17:29,005,841–29,006,414 | 108.4 kb | Distal (>10kb) Multiome | 707 | |
| chr17:29,039,928–29,040,500 | 142.6 kb | Distal (>10kb) Multiome | 99 | |
| chr17:29,042,531–29,043,259 | 145.2 kb | Distal (>10kb) Multiome | 553 | |
| chr17:29,148,688–29,149,641 | 251.3 kb | Distal (>10kb) Multiome | 709 | |
| chr17:29,176,562–29,177,220 | 279.2 kb | Distal (>10kb) Multiome | 782 | |
| chr17:29,179,268–29,180,802 | 281.8 kb | Distal (>10kb) Multiome | 781 |
Genomic view of the FLOT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.