FLOT1

flotillin 1

This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Developmental clusters: GC6 GC3

Biological processes 72 terms

COP9 signalosome (GO:0008180)GABA-ergic synapse (GO:0098982)adherens junction (GO:0005912)adherens junction (GO:0005912)adherens junction organization (GO:0034332)apical plasma membrane (GO:0016324)basolateral plasma membrane (GO:0016323)caveola (GO:0005901)caveola (GO:0005901)caveola assembly (GO:0070836)cell-cell adhesion mediated by cadherin (GO:0044331)cell-cell contact zone (GO:0044291)cell-cell contact zone (GO:0044291)cell-cell junction (GO:0005911)cell-cell junction assembly (GO:0007043)centriolar satellite (GO:0034451)cortical actin cytoskeleton (GO:0030864)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle (GO:0031410)dopaminergic synapse (GO:0098691)dopaminergic synapse (GO:0098691)early endosome (GO:0005769)endosome (GO:0005768)endosome (GO:0005768)external side of plasma membrane (GO:0009897)extracellular exosome (GO:0070062)extracellular matrix disassembly (GO:0022617)flotillin complex (GO:0016600)flotillin complex (GO:0016600)flotillin complex (GO:0016600)focal adhesion (GO:0005925)glutamatergic synapse (GO:0098978)intracellular signal transduction (GO:0035556)ionotropic glutamate receptor binding (GO:0035255)lamellipodium (GO:0030027)lysosomal membrane (GO:0005765)melanosome (GO:0042470)membrane (GO:0016020)membrane (GO:0016020)membrane raft (GO:0045121)membrane raft (GO:0045121)microtubule organizing center (GO:0005815)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane raft (GO:0044853)plasma membrane raft assembly (GO:0044854)plasma membrane raft organization (GO:0044857)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of endocytosis (GO:0045807)positive regulation of endocytosis (GO:0045807)positive regulation of endocytosis (GO:0045807)positive regulation of synaptic transmission, dopaminergic (GO:0032226)positive regulation of synaptic transmission, dopaminergic (GO:0032226)presynapse (GO:0098793)presynaptic active zone (GO:0048786)protease binding (GO:0002020)protease binding (GO:0002020)protease binding (GO:0002020)protein binding (GO:0005515)protein localization to plasma membrane (GO:0072659)protein localization to plasma membrane (GO:0072659)regulation of neurotransmitter uptake (GO:0051580)regulation of neurotransmitter uptake (GO:0051580)regulation of receptor internalization (GO:0002090)regulation of receptor internalization (GO:0002090)sarcolemma (GO:0042383)synapse (GO:0045202)uropod (GO:0001931)uropod (GO:0001931)

Expression (TPM)

TFs regulating FLOT1 0 TFs

Transcription factors with Perturb-seq knockdown data for FLOT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLOT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FLOT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLOT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:30,466,230–30,466,713	276.1 kb	Distal (>10kb) Multiome	369
chr6:30,489,117–30,490,512	252.4 kb	Distal (>10kb) Multiome	750
chr6:30,516,006–30,516,707	226.3 kb	Distal (>10kb) Multiome	739
chr6:30,555,407–30,557,765	186.0 kb	Distal (>10kb) Multiome	1161
chr6:30,570,822–30,571,949	171.3 kb	Distal (>10kb) Multiome	1000
chr6:30,614,393–30,615,939	127.5 kb	Distal (>10kb) Multiome	837
chr6:30,616,770–30,618,155	125.2 kb	Distal (>10kb) Multiome	1072
chr6:30,626,560–30,627,206	115.8 kb	Distal (>10kb) Multiome	802
chr6:30,646,505–30,648,035	95.4 kb	Distal (>10kb) Multiome	961
chr6:30,672,571–30,673,266	69.7 kb	Distal (>10kb) Multiome	812
chr6:30,679,032–30,679,479	63.5 kb	Distal (>10kb) Multiome	603
chr6:30,686,268–30,688,032	55.4 kb	Distal (>10kb) Multiome	801
chr6:30,690,445–30,691,240	51.7 kb	Distal (>10kb) Multiome	644
chr6:30,716,986–30,717,874	25.2 kb	Distal (>10kb) Multiome	1059
chr6:30,719,428–30,720,577	22.5 kb	Distal (>10kb) Multiome	724
chr6:30,721,307–30,722,103	21.2 kb	Distal (>10kb) Multiome	872
chr6:30,725,731–30,726,564	16.5 kb	Distal (>10kb) Multiome	478
chr6:30,740,996–30,745,094	56 bp	At TSS Multiome	1233
chr6:30,763,647–30,765,193	21.7 kb	Distal (>10kb) Multiome	850
chr6:30,880,638–30,881,295	138.3 kb	Distal (>10kb) Multiome	124
chr6:30,882,560–30,883,422	140.2 kb	Distal (>10kb) Multiome	308
chr6:30,883,625–30,885,122	141.7 kb	Distal (>10kb) Multiome	538
chr6:30,907,770–30,908,494	165.4 kb	Distal (>10kb) Multiome	1005
chr6:30,913,674–30,914,800	171.5 kb	Distal (>10kb) Multiome	944
chr6:30,942,475–30,943,087	200.1 kb	Distal (>10kb) Multiome	300
chr6:30,955,192–30,955,975	213.0 kb	Distal (>10kb) Multiome	524

Genome Browser

Genomic view of the FLOT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.