Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Involved in microtubule severing and negative regulation of cell migration. Located in cell leading edge. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FIGNL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FIGNL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FIGNL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:51,590,353–51,591,928 | 257.7 kb | Distal (>10kb) Multiome | 596 | |
| chr12:51,777,271–51,777,860 | 71.1 kb | Distal (>10kb) Multiome | 91 | |
| chr12:51,813,977–51,815,076 | 34.3 kb | Distal (>10kb) Multiome | 486 | |
| chr12:51,820,355–51,822,541 | 27.7 kb | Distal (>10kb) Multiome | 412 | |
| chr12:51,846,754–51,849,656 | 1.6 kb | Proximal (<10kb) Multiome | 440 | |
| chr12:51,855,903–51,856,328 | 7.2 kb | Proximal (<10kb) | 192 | |
| chr12:51,863,484–51,864,666 | 15.5 kb | Distal (>10kb) Multiome | 326 | |
| chr12:51,887,921–51,888,408 | 39.4 kb | Distal (>10kb) Multiome | 151 | |
| chr12:51,951,120–51,952,143 | 102.8 kb | Distal (>10kb) Multiome | 587 | |
| chr12:51,972,655–51,973,245 | 124.2 kb | Distal (>10kb) Multiome | 353 | |
| chr12:52,005,871–52,007,901 | 158.2 kb | Distal (>10kb) Multiome | 293 | |
| chr12:52,010,041–52,010,749 | 161.7 kb | Distal (>10kb) Multiome | 443 | |
| chr12:52,014,577–52,015,139 | 166.2 kb | Distal (>10kb) Multiome | 72 | |
| chr12:52,022,754–52,024,212 | 175.1 kb | Distal (>10kb) Multiome | 630 | |
| chr12:52,025,442–52,026,162 | 177.1 kb | Distal (>10kb) Multiome | 629 | |
| chr12:52,032,739–52,033,401 | 184.4 kb | Distal (>10kb) Multiome | 640 | |
| chr12:52,036,744–52,037,531 | 188.4 kb | Distal (>10kb) Multiome | 625 | |
| chr12:52,050,161–52,052,728 | 202.6 kb | Distal (>10kb) Multiome | 861 | |
| chr12:52,069,275–52,070,473 | 221.0 kb | Distal (>10kb) Multiome | 901 | |
| chr12:52,119,893–52,120,359 | 271.5 kb | Distal (>10kb) Multiome | 380 |
Genomic view of the FIGNL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.