Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in actin cytoskeleton organization; filopodium assembly; and regulation of cell shape. Predicted to be located in Golgi apparatus; lamellipodium; and ruffle. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FGD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:95,003,172–95,003,905 | 213.7 kb | Distal (>10kb) Multiome | 875 | |
| chr12:95,072,721–95,073,838 | 143.8 kb | Distal (>10kb) Multiome | 927 | |
| chr12:95,129,410–95,130,455 | 87.2 kb | Distal (>10kb) Multiome | 158 | |
| chr12:95,216,693–95,218,575 | 237 bp | At TSS Multiome | 1001 | |
| chr12:95,442,539–95,444,040 | 226.2 kb | Distal (>10kb) Multiome | 107 | |
| chr12:95,446,296–95,447,252 | 229.4 kb | Distal (>10kb) Multiome | 289 | |
| chr12:95,473,495–95,474,647 | 256.7 kb | Distal (>10kb) Multiome | 953 |
Genomic view of the FGD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.