Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul2-RING ubiquitin ligase complex. Is active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FEM1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FEM1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FEM1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:4,534,817–4,535,416 | 256.5 kb | Distal (>10kb) Multiome | 451 | |
| chr19:4,556,056–4,556,977 | 235.1 kb | Distal (>10kb) Multiome | 259 | |
| chr19:4,581,475–4,581,916 | 210.0 kb | Distal (>10kb) Multiome | 358 | |
| chr19:4,597,380–4,598,540 | 193.6 kb | Distal (>10kb) Multiome | 280 | |
| chr19:4,633,303–4,633,826 | 158.2 kb | Distal (>10kb) Multiome | 500 | |
| chr19:4,636,101–4,636,717 | 155.3 kb | Distal (>10kb) Multiome | 445 | |
| chr19:4,639,001–4,640,103 | 152.4 kb | Distal (>10kb) Multiome | 710 | |
| chr19:4,669,686–4,671,221 | 121.3 kb | Distal (>10kb) Multiome | 797 | |
| chr19:4,678,652–4,679,681 | 112.5 kb | Distal (>10kb) Multiome | 164 | |
| chr19:4,723,373–4,724,832 | 67.8 kb | Distal (>10kb) Multiome HiCAR | 1021 | |
| chr19:4,791,166–4,792,360 | 224 bp | At TSS Multiome | 897 | |
| chr19:4,867,260–4,868,220 | 76.0 kb | Distal (>10kb) Multiome | 718 | |
| chr19:4,908,827–4,910,489 | 118.3 kb | Distal (>10kb) Multiome | 766 | |
| chr19:4,968,227–4,969,595 | 177.2 kb | Distal (>10kb) Multiome | 764 | |
| chr19:5,048,124–5,048,589 | 256.7 kb | Distal (>10kb) Multiome | 444 |
Genomic view of the FEM1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.