Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FCF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FCF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FCF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:74,417,196–74,418,934 | 295.2 kb | Distal (>10kb) Multiome | 153 | |
| chr14:74,425,677–74,426,474 | 287.1 kb | Distal (>10kb) Multiome | 342 | |
| chr14:74,442,382–74,443,260 | 270.5 kb | Distal (>10kb) Multiome | 53 | |
| chr14:74,470,530–74,471,370 | 242.3 kb | Distal (>10kb) Multiome | 31 | |
| chr14:74,492,838–74,494,443 | 219.6 kb | Distal (>10kb) Multiome | 820 | |
| chr14:74,500,815–74,501,591 | 212.0 kb | Distal (>10kb) Multiome | 179 | |
| chr14:74,611,325–74,612,912 | 100.5 kb | Distal (>10kb) Multiome | 552 | |
| chr14:74,620,601–74,621,179 | 92.3 kb | Distal (>10kb) Multiome | 257 | |
| chr14:74,763,078–74,763,795 | 50.1 kb | Distal (>10kb) Multiome | 808 | |
| chr14:74,879,596–74,880,720 | 166.9 kb | Distal (>10kb) Multiome | 108 | |
| chr14:74,881,522–74,882,475 | 168.7 kb | Distal (>10kb) Multiome | 877 | |
| chr14:74,922,804–74,923,467 | 210.1 kb | Distal (>10kb) Multiome | 458 | |
| chr14:74,955,358–74,956,099 | 242.5 kb | Distal (>10kb) Multiome | 457 | |
| chr14:74,980,538–74,981,185 | 267.7 kb | Distal (>10kb) Multiome | 205 | |
| chr14:75,002,395–75,003,398 | 289.6 kb | Distal (>10kb) Multiome | 767 |
Genomic view of the FCF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.