This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBXO7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:32,175,754–32,176,273 | 298.7 kb | Distal (>10kb) Multiome | 106 | |
| chr22:32,202,214–32,203,260 | 272.3 kb | Distal (>10kb) Multiome | 251 | |
| chr22:32,204,184–32,205,469 | 269.8 kb | Distal (>10kb) Multiome | 338 | |
| chr22:32,206,463–32,207,219 | 267.8 kb | Distal (>10kb) Multiome | 136 | |
| chr22:32,474,361–32,475,480 | 3 bp | At TSS Multiome | 819 | |
| chr22:32,502,334–32,503,331 | 27.9 kb | Distal (>10kb) Multiome | 63 | |
| chr22:32,531,984–32,532,601 | 57.6 kb | Distal (>10kb) Multiome | 610 | |
| chr22:32,643,108–32,643,606 | 168.6 kb | Distal (>10kb) Multiome | 90 |
Genomic view of the FBXO7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.