Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]
Transcription factors with Perturb-seq knockdown data for FBXO45. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO45 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO45, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:196,273,588–196,274,153 | 294.8 kb | Distal (>10kb) Multiome | 95 | |
| chr3:196,287,125–196,288,362 | 280.8 kb | Distal (>10kb) Multiome | 979 | |
| chr3:196,317,553–196,318,672 | 250.4 kb | Distal (>10kb) Multiome | 830 | |
| chr3:196,431,516–196,433,176 | 136.1 kb | Distal (>10kb) Multiome | 851 | |
| chr3:196,503,288–196,504,272 | 64.8 kb | Distal (>10kb) Multiome | 897 | |
| chr3:196,528,585–196,529,088 | 39.7 kb | Distal (>10kb) Multiome | 425 | |
| chr3:196,568,218–196,569,450 | 109 bp | At TSS Multiome | 853 | |
| chr3:196,631,880–196,633,250 | 64.0 kb | Distal (>10kb) Multiome | 879 | |
| chr3:196,639,198–196,640,059 | 71.1 kb | Distal (>10kb) Multiome | 438 | |
| chr3:196,665,925–196,666,686 | 97.7 kb | Distal (>10kb) Multiome | 439 | |
| chr3:196,711,809–196,713,001 | 143.8 kb | Distal (>10kb) Multiome | 782 | |
| chr3:196,739,555–196,740,517 | 171.3 kb | Distal (>10kb) Multiome | 736 | |
| chr3:196,867,462–196,868,618 | 299.3 kb | Distal (>10kb) Multiome | 794 |
Genomic view of the FBXO45 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.