Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]
Transcription factors with Perturb-seq knockdown data for FBXO42. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO42 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO42, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:16,073,117–16,073,908 | 278.9 kb | Distal (>10kb) Multiome | 375 | |
| chr1:16,115,357–16,116,733 | 236.4 kb | Distal (>10kb) Multiome | 269 | |
| chr1:16,145,972–16,147,046 | 206.0 kb | Distal (>10kb) Multiome | 689 | |
| chr1:16,154,818–16,156,461 | 196.4 kb | Distal (>10kb) Multiome | 742 | |
| chr1:16,167,178–16,168,479 | 184.6 kb | Distal (>10kb) Multiome | 501 | |
| chr1:16,206,128–16,208,181 | 145.7 kb | Distal (>10kb) Multiome | 760 | |
| chr1:16,212,441–16,212,918 | 139.8 kb | Distal (>10kb) Multiome | 183 | |
| chr1:16,215,805–16,218,073 | 134.9 kb | Distal (>10kb) Multiome | 490 | |
| chr1:16,226,476–16,227,566 | 125.5 kb | Distal (>10kb) Multiome | 208 | |
| chr1:16,236,291–16,237,528 | 115.3 kb | Distal (>10kb) Multiome | 717 | |
| chr1:16,351,966–16,353,171 | 51 bp | At TSS Multiome | 894 | |
| chr1:16,366,922–16,368,057 | 14.7 kb | Distal (>10kb) Multiome | 957 | |
| chr1:16,440,240–16,440,992 | 88.1 kb | Distal (>10kb) Multiome | 936 | |
| chr1:16,498,731–16,499,831 | 146.8 kb | Distal (>10kb) Multiome | 710 | |
| chr1:16,513,524–16,514,536 | 161.6 kb | Distal (>10kb) Multiome | 716 | |
| chr1:16,534,972–16,535,673 | 182.8 kb | Distal (>10kb) Multiome | 146 | |
| chr1:16,612,236–16,614,194 | 261.1 kb | Distal (>10kb) Multiome | 1105 | |
| chr1:16,620,707–16,621,639 | 268.7 kb | Distal (>10kb) Multiome | 685 | |
| chr1:16,639,254–16,639,764 | 287.0 kb | Distal (>10kb) Multiome | 46 | |
| chr1:16,644,020–16,645,162 | 292.2 kb | Distal (>10kb) Multiome | 979 |
Genomic view of the FBXO42 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.