Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for FBXO34. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO34 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO34, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:55,026,752–55,027,732 | 244.2 kb | Distal (>10kb) Multiome | 918 | |
| chr14:55,051,004–55,052,455 | 219.7 kb | Distal (>10kb) Multiome | 1079 | |
| chr14:55,103,022–55,103,627 | 168.1 kb | Distal (>10kb) Multiome | 700 | |
| chr14:55,128,954–55,130,369 | 142.0 kb | Distal (>10kb) Multiome | 569 | |
| chr14:55,191,089–55,192,110 | 79.7 kb | Distal (>10kb) Multiome | 702 | |
| chr14:55,270,885–55,272,249 | 70 bp | At TSS Multiome | 901 | |
| chr14:55,273,960–55,274,220 | 2.5 kb | Proximal (<10kb) | 32 | |
| chr14:55,275,685–55,276,150 | 4.4 kb | Proximal (<10kb) Multiome | 15 | |
| chr14:55,276,485–55,276,945 | 5.1 kb | Proximal (<10kb) | 19 | |
| chr14:55,411,377–55,412,204 | 140.4 kb | Distal (>10kb) Multiome | 795 |
Genomic view of the FBXO34 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.