This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for FBXO17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:38,514,956–38,515,568 | 460.5 kb | Distal (>10kb) Multiome HiCAR | 404 | |
| chr19:38,683,677–38,684,144 | 292.1 kb | Distal (>10kb) Multiome | 678 | |
| chr19:38,734,491–38,735,702 | 240.4 kb | Distal (>10kb) Multiome | 338 | |
| chr19:38,735,981–38,737,634 | 238.7 kb | Distal (>10kb) Multiome | 493 | |
| chr19:38,754,913–38,755,455 | 220.5 kb | Distal (>10kb) Multiome | 12 | |
| chr19:38,831,191–38,832,119 | 143.9 kb | Distal (>10kb) Multiome | 931 | |
| chr19:38,849,166–38,852,789 | 123.7 kb | Distal (>10kb) Multiome | 1139 | |
| chr19:38,869,729–38,870,536 | 105.7 kb | Distal (>10kb) Multiome | 350 | |
| chr19:38,899,267–38,900,530 | 75.9 kb | Distal (>10kb) Multiome | 886 | |
| chr19:38,930,044–38,931,363 | 45.0 kb | Distal (>10kb) Multiome | 889 | |
| chr19:38,949,549–38,950,582 | 25.8 kb | Distal (>10kb) Multiome | 330 | |
| chr19:38,975,192–38,976,859 | 982 bp | At TSS Multiome | 846 | |
| chr19:38,995,916–38,996,388 | 20.4 kb | Distal (>10kb) Multiome | 144 | |
| chr19:39,030,958–39,033,042 | 55.9 kb | Distal (>10kb) Multiome | 763 | |
| chr19:39,125,485–39,126,290 | 150.0 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the FBXO17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.