Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for FBXO10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:37,415,054–37,415,560 | 161.0 kb | Distal (>10kb) Multiome | 414 | |
| chr9:37,422,138–37,423,121 | 153.7 kb | Distal (>10kb) Multiome | 814 | |
| chr9:37,464,634–37,466,782 | 110.8 kb | Distal (>10kb) Multiome | 997 | |
| chr9:37,485,291–37,486,541 | 90.5 kb | Distal (>10kb) Multiome | 734 | |
| chr9:37,574,572–37,574,723 | 1.6 kb | Proximal (<10kb) | 53 | |
| chr9:37,575,608–37,576,724 | 24 bp | At TSS Multiome | 608 | |
| chr9:37,592,006–37,592,956 | 16.2 kb | Distal (>10kb) Multiome | 990 | |
| chr9:37,650,357–37,651,703 | 74.6 kb | Distal (>10kb) Multiome | 403 | |
| chr9:37,751,142–37,751,941 | 175.2 kb | Distal (>10kb) Multiome | 38 | |
| chr9:37,753,624–37,754,122 | 177.5 kb | Distal (>10kb) Multiome | 540 | |
| chr9:37,784,663–37,785,433 | 208.7 kb | Distal (>10kb) Multiome | 859 | |
| chr9:37,800,307–37,801,695 | 224.4 kb | Distal (>10kb) Multiome | 1104 |
Genomic view of the FBXO10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.