Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for FBRS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBRS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBRS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:30,369,220–30,371,611 | 287.7 kb | Distal (>10kb) Multiome | 818 | |
| chr16:30,377,495–30,379,532 | 280.1 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,394,422–30,396,098 | 263.2 kb | Distal (>10kb) Multiome | 941 | |
| chr16:30,400,026–30,401,048 | 257.9 kb | Distal (>10kb) Multiome | 839 | |
| chr16:30,406,974–30,408,429 | 250.9 kb | Distal (>10kb) Multiome | 908 | |
| chr16:30,417,414–30,418,576 | 240.4 kb | Distal (>10kb) Multiome | 543 | |
| chr16:30,429,571–30,430,773 | 228.2 kb | Distal (>10kb) Multiome HiCAR | 1060 | |
| chr16:30,445,340–30,446,062 | 212.6 kb | Distal (>10kb) Multiome | 898 | |
| chr16:30,526,068–30,527,896 | 131.0 kb | Distal (>10kb) Multiome | 1004 | |
| chr16:30,534,370–30,535,460 | 123.6 kb | Distal (>10kb) Multiome | 957 | |
| chr16:30,557,913–30,558,847 | 100.0 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,571,001–30,572,505 | 86.4 kb | Distal (>10kb) Multiome | 950 | |
| chr16:30,585,243–30,586,223 | 72.6 kb | Distal (>10kb) Multiome | 588 | |
| chr16:30,609,586–30,610,748 | 48.0 kb | Distal (>10kb) Multiome | 1030 | |
| chr16:30,634,070–30,634,986 | 24.0 kb | Distal (>10kb) Multiome | 907 | |
| chr16:30,650,029–30,651,831 | 7.7 kb | Proximal (<10kb) Multiome | 992 | |
| chr16:30,657,638–30,659,894 | 128 bp | At TSS Multiome | 1053 | |
| chr16:30,677,814–30,678,622 | 19.8 kb | Distal (>10kb) Multiome | 177 | |
| chr16:30,697,755–30,699,614 | 40.7 kb | Distal (>10kb) Multiome | 1153 | |
| chr16:30,747,864–30,748,943 | 89.9 kb | Distal (>10kb) Multiome | 824 | |
| chr16:30,761,380–30,762,606 | 103.8 kb | Distal (>10kb) Multiome | 885 | |
| chr16:30,774,965–30,776,186 | 117.1 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,786,385–30,788,019 | 128.7 kb | Distal (>10kb) Multiome | 885 | |
| chr16:30,805,468–30,806,187 | 147.2 kb | Distal (>10kb) Multiome | 969 | |
| chr16:30,814,045–30,814,733 | 156.0 kb | Distal (>10kb) Multiome | 995 | |
| chr16:30,841,062–30,841,882 | 183.1 kb | Distal (>10kb) Multiome | 49 | |
| chr16:30,874,866–30,875,643 | 216.9 kb | Distal (>10kb) Multiome | 1108 | |
| chr16:30,893,485–30,894,587 | 235.7 kb | Distal (>10kb) Multiome | 950 | |
| chr16:30,895,854–30,897,426 | 238.6 kb | Distal (>10kb) Multiome | 822 | |
| chr16:30,901,969–30,902,794 | 243.9 kb | Distal (>10kb) Multiome | 579 | |
| chr16:30,921,611–30,925,097 | 265.0 kb | Distal (>10kb) Multiome | 1132 | |
| chr16:30,927,705–30,928,596 | 269.7 kb | Distal (>10kb) Multiome | 274 | |
| chr16:30,941,803–30,942,254 | 283.7 kb | Distal (>10kb) Multiome | 507 | |
| chr16:30,947,471–30,950,635 | 291.8 kb | Distal (>10kb) Multiome | 1066 | |
| chr16:30,953,370–30,954,135 | 295.4 kb | Distal (>10kb) Multiome | 499 | |
| chr16:30,956,960–30,958,498 | 299.3 kb | Distal (>10kb) Multiome | 1022 |
Genomic view of the FBRS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.