FBN3

fibrillin 3 | KIAA1776

This gene encodes a memebr of the fibrillin protein family. Fibrillins are extracellular matrix molecules that assemble into microfibrils in many connective tissues. This gene is most highly expressed in fetal tissues and its protein product is localized to extracellular microfibrils of developing skeletal elements, skin, lung, kidney, and skeletal muscle. This gene is potentially involved in Weill-Marchesani syndrome. [provided by RefSeq, Mar 2016]

Member of: DE-4 DE-4.14 Developmental clusters: GC7

Biological processes 12 terms

calcium ion binding (GO:0005509)camera-type eye development (GO:0043010)embryonic eye morphogenesis (GO:0048048)extracellular matrix (GO:0031012)extracellular matrix constituent conferring elasticity (GO:0030023)extracellular matrix structural constituent (GO:0005201)extracellular region (GO:0005576)glucose homeostasis (GO:0042593)glucose metabolic process (GO:0006006)hormone activity (GO:0005179)microfibril (GO:0001527)signal transduction (GO:0007165)

Expression (TPM)

TFs regulating FBN3 0 TFs

Transcription factors with Perturb-seq knockdown data for FBN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FBN3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:7,853,168–7,853,781	296.1 kb	Distal (>10kb) Multiome	747
chr19:7,861,607–7,864,383	286.9 kb	Distal (>10kb) Multiome	348
chr19:7,868,454–7,870,252	280.2 kb	Distal (>10kb) Multiome	721
chr19:7,871,072–7,872,772	277.5 kb	Distal (>10kb) Multiome	487
chr19:7,873,962–7,875,061	275.0 kb	Distal (>10kb) Multiome	416
chr19:7,888,334–7,888,798	261.1 kb	Distal (>10kb) Multiome	509
chr19:7,902,730–7,904,931	245.8 kb	Distal (>10kb) Multiome	1000
chr19:7,917,358–7,918,182	231.7 kb	Distal (>10kb) Multiome	316
chr19:7,919,934–7,921,640	228.9 kb	Distal (>10kb) Multiome	802
chr19:7,924,612–7,926,698	224.3 kb	Distal (>10kb) Multiome	766
chr19:7,943,338–7,944,472	205.8 kb	Distal (>10kb) Multiome	974
chr19:8,001,954–8,002,874	147.1 kb	Distal (>10kb) Multiome	475
chr19:8,005,202–8,006,197	143.9 kb	Distal (>10kb) Multiome	729
chr19:8,028,908–8,029,518	120.3 kb	Distal (>10kb) Multiome	122
chr19:8,050,174–8,051,154	98.9 kb	Distal (>10kb) Multiome	467
chr19:8,148,316–8,149,986	90 bp	At TSS Multiome	381
chr19:8,158,576–8,158,773	9.0 kb	Proximal (<10kb)	378
chr19:8,203,277–8,204,384	54.3 kb	Distal (>10kb) Multiome	150
chr19:8,208,086–8,210,178	59.6 kb	Distal (>10kb) Multiome	712
chr19:8,268,737–8,269,370	119.4 kb	Distal (>10kb) Multiome	272
chr19:8,307,739–8,308,717	158.7 kb	Distal (>10kb) Multiome	973
chr19:8,314,738–8,315,490	165.5 kb	Distal (>10kb) Multiome	49
chr19:8,320,824–8,321,811	171.8 kb	Distal (>10kb) Multiome	871
chr19:8,334,500–8,335,843	185.7 kb	Distal (>10kb) Multiome	384
chr19:8,342,762–8,343,678	193.7 kb	Distal (>10kb) Multiome	440
chr19:8,363,586–8,364,765	214.5 kb	Distal (>10kb) Multiome	549
chr19:8,389,684–8,391,548	240.6 kb	Distal (>10kb) Multiome	878
chr19:8,412,769–8,413,775	263.6 kb	Distal (>10kb) Multiome	566
chr19:8,444,605–8,445,806	295.3 kb	Distal (>10kb) Multiome	910

Genome Browser

Genomic view of the FBN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.