This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Transcription factors with Perturb-seq knockdown data for FARP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FARP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FARP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:97,851,174–97,851,752 | 291.9 kb | Distal (>10kb) Multiome | 134 | |
| chr13:97,975,374–97,977,544 | 167.0 kb | Distal (>10kb) Multiome | 807 | |
| chr13:98,133,472–98,134,149 | 9.7 kb | Proximal (<10kb) Multiome | 131 | |
| chr13:98,141,989–98,143,988 | 346 bp | At TSS Multiome | 743 | |
| chr13:98,146,610–98,146,848 | 3.2 kb | Proximal (<10kb) | 244 | |
| chr13:98,163,973–98,164,873 | 21.1 kb | Distal (>10kb) Multiome | 68 | |
| chr13:98,272,199–98,273,632 | 129.5 kb | Distal (>10kb) Multiome | 277 | |
| chr13:98,320,222–98,321,259 | 177.3 kb | Distal (>10kb) Multiome HiCAR | 79 | |
| chr13:98,328,019–98,328,477 | 184.8 kb | Distal (>10kb) Multiome HiCAR | 154 |
Genomic view of the FARP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.