This gene encodes a ubiquitin ligase that is a member of the Fanconi anemia complementation group (FANC). Members of this group are related by their assembly into a common nuclear protein complex rather than by sequence similarity. This gene encodes the protein for complementation group L that mediates monoubiquitination of FANCD2 as well as FANCI. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2018]
Transcription factors with Perturb-seq knockdown data for FANCL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FANCL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FANCL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:58,045,857–58,047,827 | 194.5 kb | Distal (>10kb) Multiome | 1094 | |
| chr2:58,206,941–58,207,510 | 6.1 kb | Proximal (<10kb) | 52 | |
| chr2:58,237,780–58,238,125 | 3.2 kb | Proximal (<10kb) | 100 | |
| chr2:58,240,694–58,241,751 | 57 bp | At TSS Multiome | 963 | |
| chr2:58,242,848–58,243,031 | 1.5 kb | Proximal (<10kb) | 6 | |
| chr2:58,312,368–58,313,254 | 71.5 kb | Distal (>10kb) Multiome | 66 | |
| chr2:58,427,459–58,429,418 | 187.4 kb | Distal (>10kb) Multiome | 520 | |
| chr2:58,434,509–58,435,726 | 194.0 kb | Distal (>10kb) Multiome | 131 | |
| chr2:58,447,649–58,448,569 | 206.9 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr2:58,535,035–58,535,588 | 294.1 kb | Distal (>10kb) Multiome | 228 |
Genomic view of the FANCL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.