The protein encoded by this gene has homologs that have been identified in mouse, macaque, etc organisms. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for FAM219A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM219A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM219A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,178,460–34,179,845 | 279.5 kb | Distal (>10kb) Multiome | 814 | |
| chr9:34,328,711–34,329,961 | 129.1 kb | Distal (>10kb) Multiome | 768 | |
| chr9:34,363,597–34,364,212 | 94.6 kb | Distal (>10kb) Multiome | 104 | |
| chr9:34,374,953–34,375,681 | 83.3 kb | Distal (>10kb) Multiome | 432 | |
| chr9:34,376,008–34,377,655 | 81.5 kb | Distal (>10kb) Multiome | 779 | |
| chr9:34,379,248–34,381,674 | 77.6 kb | Distal (>10kb) Multiome | 763 | |
| chr9:34,451,289–34,451,492 | 7.1 kb | Proximal (<10kb) | 49 | |
| chr9:34,456,881–34,459,235 | 103 bp | At TSS Multiome | 704 | |
| chr9:34,522,211–34,523,972 | 64.6 kb | Distal (>10kb) Multiome | 473 | |
| chr9:34,577,374–34,578,752 | 119.5 kb | Distal (>10kb) Multiome | 204 | |
| chr9:34,589,298–34,591,068 | 131.3 kb | Distal (>10kb) Multiome | 258 | |
| chr9:34,591,283–34,592,013 | 133.3 kb | Distal (>10kb) Multiome | 368 | |
| chr9:34,611,663–34,612,738 | 153.6 kb | Distal (>10kb) Multiome | 680 | |
| chr9:34,612,834–34,613,263 | 154.6 kb | Distal (>10kb) Multiome | 343 | |
| chr9:34,620,108–34,620,704 | 162.0 kb | Distal (>10kb) Multiome | 467 | |
| chr9:34,628,770–34,629,308 | 170.5 kb | Distal (>10kb) Multiome | 216 | |
| chr9:34,637,123–34,638,475 | 179.3 kb | Distal (>10kb) Multiome | 872 | |
| chr9:34,646,247–34,647,338 | 188.2 kb | Distal (>10kb) Multiome | 857 | |
| chr9:34,651,771–34,652,431 | 193.6 kb | Distal (>10kb) Multiome | 669 | |
| chr9:34,664,346–34,666,446 | 207.0 kb | Distal (>10kb) Multiome | 707 | |
| chr9:34,674,895–34,675,574 | 216.7 kb | Distal (>10kb) Multiome | 372 | |
| chr9:34,701,127–34,701,863 | 242.9 kb | Distal (>10kb) Multiome | 390 |
Genomic view of the FAM219A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.