FAM168A

family with sequence similarity 168 member A | TCRP1, KIAA0280

Involved in positive regulation of base-excision repair. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 DE-2.7 Developmental clusters: GC6

Biological processes 3 terms

positive regulation of base-excision repair (GO:1905053)positive regulation of base-excision repair (GO:1905053)protein binding (GO:0005515)

Expression (TPM)

TFs regulating FAM168A 0 TFs

Transcription factors with Perturb-seq knockdown data for FAM168A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM168A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FAM168A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM168A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:73,307,026–73,309,843	290.5 kb	Distal (>10kb) Multiome	963
chr11:73,342,698–73,343,488	255.1 kb	Distal (>10kb) Multiome	124
chr11:73,361,895–73,362,672	235.9 kb	Distal (>10kb) Multiome	245
chr11:73,375,760–73,377,389	221.8 kb	Distal (>10kb) Multiome	817
chr11:73,597,688–73,598,911	212 bp	At TSS Multiome	887
chr11:73,645,683–73,646,788	48.1 kb	Distal (>10kb) Multiome	193
chr11:73,647,445–73,647,968	49.5 kb	Distal (>10kb) Multiome	442
chr11:73,660,644–73,661,627	63.1 kb	Distal (>10kb) Multiome	525
chr11:73,760,242–73,761,712	163.1 kb	Distal (>10kb) Multiome	842
chr11:73,779,162–73,780,136	181.5 kb	Distal (>10kb) Multiome	920
chr11:73,787,771–73,788,337	190.0 kb	Distal (>10kb) Multiome	1000
chr11:73,876,432–73,877,378	278.8 kb	Distal (>10kb) Multiome	911

Genome Browser

Genomic view of the FAM168A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.