Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. Implicated in chronic obstructive pulmonary disease. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM13A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM13A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM13A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:88,822,957–88,823,906 | 233.7 kb | Distal (>10kb) Multiome HiCAR | 731 | |
| chr4:89,054,500–89,054,653 | 2.5 kb | Proximal (<10kb) | 12 | |
| chr4:89,054,772–89,054,905 | 2.3 kb | Proximal (<10kb) | 13 | |
| chr4:89,056,706–89,057,525 | 3 bp | At TSS Multiome | 504 | |
| chr4:89,110,600–89,112,226 | 54.3 kb | Distal (>10kb) Multiome | 989 | |
| chr4:89,226,645–89,227,470 | 169.9 kb | Distal (>10kb) Multiome | 313 | |
| chr4:89,307,277–89,308,558 | 250.7 kb | Distal (>10kb) Multiome | 440 |
Genomic view of the FAM13A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.