Transcription factors with Perturb-seq knockdown data for FAM117A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM117A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM117A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:49,494,780–49,495,773 | 294.0 kb | Distal (>10kb) Multiome | 386 | |
| chr17:49,496,269–49,496,902 | 292.6 kb | Distal (>10kb) Multiome | 440 | |
| chr17:49,497,462–49,497,966 | 291.3 kb | Distal (>10kb) Multiome | 280 | |
| chr17:49,508,179–49,508,962 | 280.6 kb | Distal (>10kb) Multiome | 380 | |
| chr17:49,556,195–49,556,772 | 232.7 kb | Distal (>10kb) Multiome | 636 | |
| chr17:49,567,907–49,568,549 | 221.0 kb | Distal (>10kb) Multiome | 623 | |
| chr17:49,569,780–49,570,501 | 219.0 kb | Distal (>10kb) Multiome | 893 | |
| chr17:49,575,427–49,577,397 | 212.5 kb | Distal (>10kb) Multiome | 657 | |
| chr17:49,677,242–49,678,492 | 111.1 kb | Distal (>10kb) Multiome | 1110 | |
| chr17:49,707,638–49,708,519 | 80.9 kb | Distal (>10kb) Multiome | 927 | |
| chr17:49,763,285–49,764,743 | 24.9 kb | Distal (>10kb) Multiome | 768 | |
| chr17:49,788,330–49,789,442 | 637 bp | At TSS Multiome | 1068 | |
| chr17:49,851,098–49,852,060 | 62.7 kb | Distal (>10kb) Multiome | 614 | |
| chr17:49,865,367–49,866,210 | 76.7 kb | Distal (>10kb) Multiome | 213 | |
| chr17:49,880,287–49,880,820 | 91.5 kb | Distal (>10kb) Multiome | 493 | |
| chr17:49,910,218–49,910,854 | 121.4 kb | Distal (>10kb) Multiome | 230 | |
| chr17:49,968,328–49,969,629 | 179.9 kb | Distal (>10kb) Multiome | 702 | |
| chr17:49,993,266–49,993,947 | 204.4 kb | Distal (>10kb) Multiome | 222 | |
| chr17:49,994,638–49,995,383 | 206.0 kb | Distal (>10kb) Multiome | 281 | |
| chr17:49,996,642–49,997,221 | 207.7 kb | Distal (>10kb) Multiome | 470 | |
| chr17:50,055,522–50,057,280 | 266.8 kb | Distal (>10kb) Multiome | 654 |
Genomic view of the FAM117A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.