This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for EXOSC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOSC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOSC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:37,485,291–37,486,541 | 299.2 kb | Distal (>10kb) Multiome | 734 | |
| chr9:37,575,608–37,576,724 | 208.7 kb | Distal (>10kb) Multiome | 608 | |
| chr9:37,592,006–37,592,956 | 192.5 kb | Distal (>10kb) Multiome | 990 | |
| chr9:37,650,357–37,651,703 | 134.1 kb | Distal (>10kb) Multiome | 403 | |
| chr9:37,751,142–37,751,941 | 33.5 kb | Distal (>10kb) Multiome | 38 | |
| chr9:37,753,624–37,754,122 | 31.2 kb | Distal (>10kb) Multiome | 540 | |
| chr9:37,784,663–37,785,433 | 9 bp | At TSS Multiome | 859 | |
| chr9:37,787,123–37,787,376 | 2.1 kb | Proximal (<10kb) | 91 | |
| chr9:37,800,307–37,801,695 | 15.7 kb | Distal (>10kb) Multiome | 1104 | |
| chr9:37,903,405–37,904,985 | 119.2 kb | Distal (>10kb) Multiome | 1045 | |
| chr9:37,913,669–37,914,191 | 128.8 kb | Distal (>10kb) Multiome | 509 | |
| chr9:37,922,396–37,923,788 | 138.3 kb | Distal (>10kb) Multiome | 162 | |
| chr9:38,017,105–38,017,773 | 232.3 kb | Distal (>10kb) Multiome | 267 | |
| chr9:38,066,700–38,070,292 | 284.6 kb | Distal (>10kb) Multiome | 922 |
Genomic view of the EXOSC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.