This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for EXOG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:38,136,419–38,139,307 | 357.6 kb | Distal (>10kb) Multiome HiCAR | 989 | |
| chr3:38,345,594–38,347,388 | 149.5 kb | Distal (>10kb) Multiome HiCAR | 971 | |
| chr3:38,452,852–38,456,220 | 42.6 kb | Distal (>10kb) Multiome | 971 | |
| chr3:38,495,771–38,496,881 | 28 bp | At TSS Multiome | 764 | |
| chr3:38,580,074–38,580,574 | 84.0 kb | Distal (>10kb) Multiome | 109 | |
| chr3:38,601,761–38,602,426 | 105.8 kb | Distal (>10kb) Multiome | 48 | |
| chr3:38,640,708–38,641,494 | 144.8 kb | Distal (>10kb) Multiome HiCAR | 182 | |
| chr3:38,649,012–38,650,212 | 153.4 kb | Distal (>10kb) Multiome HiCAR | 437 | |
| chr3:38,651,034–38,651,663 | 155.0 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr3:38,669,439–38,670,183 | 173.5 kb | Distal (>10kb) Multiome | 85 |
Genomic view of the EXOG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.