EXD2
exonuclease 3'-5' domain containing 2 | FLJ10738, C14orf114, EXDL2

Enables 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Involved in DNA double-strand break processing; double-strand break repair via homologous recombination; and replication fork processing. Located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5 DE-5.2 Developmental clusters: GC6
Biological processes 31 terms
3'-5' exonuclease activity (GO:0008408)3'-5' exonuclease activity (GO:0008408)3'-5' exonuclease activity (GO:0008408)3'-5' exonuclease activity (GO:0008408)3'-5'-DNA exonuclease activity (GO:0008296)3'-5'-RNA exonuclease activity (GO:0000175)3'-5'-RNA exonuclease activity (GO:0000175)DNA double-strand break processing (GO:0000729)DNA recombination (GO:0006310)chromosome (GO:0005694)cytoplasm (GO:0005737)double-strand break repair (GO:0006302)double-strand break repair via homologous recombination (GO:0000724)magnesium ion binding (GO:0000287)manganese ion binding (GO:0030145)mitochondrial matrix (GO:0005759)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)nucleic acid binding (GO:0003676)nucleic acid metabolic process (GO:0090304)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)replication fork processing (GO:0031297)single-stranded DNA 3'-5' DNA exonuclease activity (GO:0008310)single-stranded DNA 3'-5' DNA exonuclease activity (GO:0008310)site of DNA damage (GO:0090734)
Expression (TPM)
EXD2 — as a Regulated Gene

TFs regulating EXD2 0 TFs

Transcription factors with Perturb-seq knockdown data for EXD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to EXD2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:68,937,585–68,939,538 252.8 kb Distal (>10kb) Multiome 580
chr14:68,977,829–68,980,593 212.1 kb Distal (>10kb) Multiome 919
chr14:69,050,256–69,051,065 140.8 kb Distal (>10kb) Multiome 105
chr14:69,129,353–69,129,859 62.0 kb Distal (>10kb) Multiome 260
chr14:69,149,737–69,150,445 41.5 kb Distal (>10kb) Multiome 70
chr14:69,151,308–69,153,780 39.9 kb Distal (>10kb) Multiome 936
chr14:69,183,867–69,184,070 7.5 kb Proximal (<10kb) 61
chr14:69,191,332–69,192,132 100 bp At TSS Multiome 977
chr14:69,259,475–69,261,593 68.3 kb Distal (>10kb) Multiome 477
chr14:69,397,842–69,399,035 207.0 kb Distal (>10kb) Multiome 926
chr14:69,483,950–69,485,210 293.1 kb Distal (>10kb) Multiome 334

Genome Browser

Genomic view of the EXD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:68,927,585 – 69,495,210
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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