This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ETNK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ETNK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ETNK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:22,333,730–22,336,157 | 289.6 kb | Distal (>10kb) Multiome | 600 | |
| chr12:22,353,447–22,354,267 | 271.3 kb | Distal (>10kb) Multiome | 141 | |
| chr12:22,376,592–22,377,286 | 248.2 kb | Distal (>10kb) Multiome | 149 | |
| chr12:22,436,588–22,437,692 | 187.9 kb | Distal (>10kb) Multiome | 80 | |
| chr12:22,443,250–22,443,763 | 181.6 kb | Distal (>10kb) Multiome | 286 | |
| chr12:22,543,368–22,545,088 | 80.6 kb | Distal (>10kb) Multiome | 1040 | |
| chr12:22,624,339–22,626,265 | 78 bp | At TSS Multiome | 1049 | |
| chr12:22,635,107–22,635,538 | 9.9 kb | Proximal (<10kb) | 30 | |
| chr12:22,699,795–22,700,629 | 74.7 kb | Distal (>10kb) Multiome | 93 | |
| chr12:22,700,769–22,701,762 | 76.2 kb | Distal (>10kb) Multiome | 149 | |
| chr12:22,858,644–22,859,647 | 234.0 kb | Distal (>10kb) Multiome | 205 | |
| chr12:22,915,885–22,917,073 | 291.2 kb | Distal (>10kb) Multiome | 125 | |
| chr12:22,924,088–22,924,950 | 299.4 kb | Distal (>10kb) Multiome | 60 |
Genomic view of the ETNK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.