ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
Transcription factors with Perturb-seq knockdown data for ESRP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ESRP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ESRP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,935,189–67,936,596 | 300.3 kb | Distal (>10kb) Multiome | 980 | |
| chr16:67,963,746–67,964,209 | 272.2 kb | Distal (>10kb) Multiome | 161 | |
| chr16:67,968,087–67,969,341 | 267.5 kb | Distal (>10kb) Multiome | 861 | |
| chr16:67,993,130–67,993,736 | 242.7 kb | Distal (>10kb) Multiome HiCAR | 790 | |
| chr16:68,019,222–68,020,043 | 216.7 kb | Distal (>10kb) Multiome | 108 | |
| chr16:68,022,490–68,023,556 | 212.9 kb | Distal (>10kb) Multiome | 958 | |
| chr16:68,084,205–68,086,133 | 150.9 kb | Distal (>10kb) Multiome HiCAR | 1092 | |
| chr16:68,235,016–68,238,254 | 20 bp | At TSS Multiome | 1055 | |
| chr16:68,239,582–68,240,355 | 3.9 kb | Proximal (<10kb) Multiome | 223 | |
| chr16:68,244,730–68,245,757 | 9.1 kb | Proximal (<10kb) Multiome | 803 | |
| chr16:68,264,033–68,265,087 | 28.3 kb | Distal (>10kb) Multiome | 876 | |
| chr16:68,310,451–68,311,505 | 74.9 kb | Distal (>10kb) Multiome | 1061 | |
| chr16:68,328,654–68,329,423 | 92.7 kb | Distal (>10kb) Multiome | 438 | |
| chr16:68,420,400–68,420,906 | 184.5 kb | Distal (>10kb) Multiome | 58 | |
| chr16:68,447,981–68,449,250 | 212.5 kb | Distal (>10kb) Multiome | 795 | |
| chr16:68,520,489–68,521,019 | 284.7 kb | Distal (>10kb) Multiome | 602 | |
| chr16:68,528,418–68,529,128 | 292.6 kb | Distal (>10kb) Multiome | 552 | |
| chr16:68,529,733–68,530,671 | 294.1 kb | Distal (>10kb) Multiome | 831 |
Genomic view of the ESRP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.