Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ESF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ESF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ESF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:13,638,235–13,639,573 | 145.9 kb | Distal (>10kb) Multiome | 858 | |
| chr20:13,780,513–13,780,742 | 4.2 kb | Proximal (<10kb) | 6 | |
| chr20:13,784,410–13,785,713 | 116 bp | At TSS Multiome | 1055 | |
| chr20:13,788,304–13,788,475 | 3.4 kb | Proximal (<10kb) | 149 | |
| chr20:13,849,862–13,851,076 | 65.5 kb | Distal (>10kb) Multiome | 199 | |
| chr20:13,873,896–13,875,288 | 89.8 kb | Distal (>10kb) Multiome | 154 | |
| chr20:13,994,818–13,996,684 | 210.5 kb | Distal (>10kb) Multiome | 614 |
Genomic view of the ESF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.