Transcription factors with Perturb-seq knockdown data for ERICH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERICH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERICH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:170,324,455–170,325,287 | 446.0 kb | Distal (>10kb) Multiome HiCAR | 406 | |
| chr2:170,530,034–170,531,403 | 240.4 kb | Distal (>10kb) Multiome | 587 | |
| chr2:170,696,280–170,697,478 | 73.8 kb | Distal (>10kb) Multiome | 123 | |
| chr2:170,711,360–170,712,724 | 58.9 kb | Distal (>10kb) Multiome | 753 | |
| chr2:170,713,092–170,717,699 | 55.7 kb | Distal (>10kb) Multiome | 1155 | |
| chr2:170,764,641–170,765,221 | 5.9 kb | Proximal (<10kb) Multiome | 96 | |
| chr2:170,770,133–170,771,632 | 29 bp | At TSS Multiome | 841 | |
| chr2:170,814,981–170,816,480 | 44.9 kb | Distal (>10kb) Multiome | 523 | |
| chr2:170,816,723–170,818,614 | 47.3 kb | Distal (>10kb) Multiome | 458 | |
| chr2:170,819,935–170,820,669 | 49.4 kb | Distal (>10kb) Multiome | 95 | |
| chr2:170,823,170–170,823,953 | 52.8 kb | Distal (>10kb) Multiome | 223 | |
| chr2:170,873,044–170,873,708 | 102.4 kb | Distal (>10kb) Multiome | 509 | |
| chr2:170,917,144–170,918,588 | 146.9 kb | Distal (>10kb) Multiome | 221 | |
| chr2:170,928,198–170,930,434 | 158.2 kb | Distal (>10kb) Multiome | 1135 | |
| chr2:170,973,304–170,974,525 | 202.7 kb | Distal (>10kb) Multiome | 906 |
Genomic view of the ERICH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.