Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for EPHX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPHX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPHX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:225,424,635–225,425,809 | 384.9 kb | Distal (>10kb) Multiome HiCAR | 399 | |
| chr1:225,427,208–225,428,777 | 382.0 kb | Distal (>10kb) Multiome HiCAR | 921 | |
| chr1:225,446,105–225,447,138 | 363.6 kb | Distal (>10kb) Multiome HiCAR | 178 | |
| chr1:225,474,969–225,475,612 | 335.0 kb | Distal (>10kb) Multiome HiCAR | 742 | |
| chr1:225,627,340–225,627,898 | 182.5 kb | Distal (>10kb) Multiome | 254 | |
| chr1:225,652,334–225,654,131 | 156.9 kb | Distal (>10kb) Multiome | 786 | |
| chr1:225,754,870–225,755,548 | 55.0 kb | Distal (>10kb) Multiome | 382 | |
| chr1:225,768,775–225,769,570 | 40.9 kb | Distal (>10kb) Multiome | 313 | |
| chr1:225,771,884–225,772,638 | 37.7 kb | Distal (>10kb) Multiome | 488 | |
| chr1:225,777,167–225,778,412 | 32.4 kb | Distal (>10kb) Multiome | 942 | |
| chr1:225,809,711–225,811,548 | 49 bp | At TSS Multiome | 654 | |
| chr1:225,811,709–225,811,876 | 1.6 kb | Proximal (<10kb) | 110 | |
| chr1:225,845,424–225,846,556 | 35.8 kb | Distal (>10kb) Multiome | 416 | |
| chr1:225,881,255–225,884,173 | 72.2 kb | Distal (>10kb) Multiome | 879 | |
| chr1:225,888,552–225,889,596 | 79.1 kb | Distal (>10kb) Multiome | 185 | |
| chr1:225,898,735–225,899,922 | 89.4 kb | Distal (>10kb) Multiome | 335 | |
| chr1:225,903,782–225,904,454 | 93.9 kb | Distal (>10kb) Multiome | 40 | |
| chr1:225,908,825–225,909,327 | 98.9 kb | Distal (>10kb) Multiome | 101 | |
| chr1:225,910,978–225,911,799 | 101.3 kb | Distal (>10kb) Multiome | 344 | |
| chr1:225,923,776–225,924,773 | 114.2 kb | Distal (>10kb) Multiome | 960 | |
| chr1:225,939,444–225,939,998 | 129.5 kb | Distal (>10kb) Multiome | 62 | |
| chr1:225,945,518–225,946,038 | 135.6 kb | Distal (>10kb) Multiome | 172 | |
| chr1:225,948,616–225,949,435 | 138.9 kb | Distal (>10kb) Multiome | 175 | |
| chr1:225,957,776–225,958,797 | 148.2 kb | Distal (>10kb) Multiome | 175 | |
| chr1:225,999,043–226,000,159 | 189.4 kb | Distal (>10kb) Multiome | 969 | |
| chr1:226,061,587–226,063,333 | 252.4 kb | Distal (>10kb) Multiome | 976 | |
| chr1:226,082,913–226,084,135 | 273.5 kb | Distal (>10kb) Multiome | 852 | |
| chr1:226,109,567–226,111,083 | 299.9 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the EPHX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.