Transcription factors with Perturb-seq knockdown data for EPB41L4A-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPB41L4A-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPB41L4A-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:111,511,588–111,513,437 | 648.3 kb | Distal (>10kb) Multiome HiCAR | 1035 | |
| chr5:111,548,011–111,549,940 | 612.1 kb | Distal (>10kb) Multiome HiCAR | 416 | |
| chr5:111,934,060–111,935,563 | 226.0 kb | Distal (>10kb) Multiome | 205 | |
| chr5:112,108,993–112,109,919 | 51.5 kb | Distal (>10kb) Multiome | 166 | |
| chr5:112,160,273–112,161,560 | 53 bp | At TSS Multiome | 1064 | |
| chr5:112,164,566–112,164,833 | 3.7 kb | Proximal (<10kb) | 24 | |
| chr5:112,165,948–112,167,034 | 5.6 kb | Proximal (<10kb) Multiome | 403 | |
| chr5:112,169,781–112,169,961 | 8.9 kb | Proximal (<10kb) | 20 | |
| chr5:112,205,632–112,206,447 | 45.2 kb | Distal (>10kb) Multiome | 253 | |
| chr5:112,417,921–112,420,785 | 257.2 kb | Distal (>10kb) Multiome | 740 |
Genomic view of the EPB41L4A-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.