Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for EPB41L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPB41L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPB41L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:35,953,663–35,955,230 | 200.2 kb | Distal (>10kb) Multiome HiCAR | 1166 | |
| chr20:36,010,700–36,011,324 | 143.8 kb | Distal (>10kb) Multiome | 70 | |
| chr20:36,050,468–36,051,316 | 103.8 kb | Distal (>10kb) Multiome | 1033 | |
| chr20:36,064,282–36,065,619 | 89.9 kb | Distal (>10kb) Multiome | 798 | |
| chr20:36,092,411–36,092,942 | 62.2 kb | Distal (>10kb) Multiome | 320 | |
| chr20:36,154,232–36,155,251 | 120 bp | At TSS Multiome | 526 | |
| chr20:36,156,555–36,156,944 | 1.8 kb | Proximal (<10kb) | 268 | |
| chr20:36,259,130–36,259,999 | 104.7 kb | Distal (>10kb) Multiome | 159 | |
| chr20:36,306,218–36,306,746 | 151.6 kb | Distal (>10kb) Multiome | 148 | |
| chr20:36,399,522–36,399,982 | 245.1 kb | Distal (>10kb) Multiome | 345 | |
| chr20:36,435,969–36,436,607 | 281.6 kb | Distal (>10kb) Multiome HiCAR | 268 |
Genomic view of the EPB41L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.