Enables ubiquitin ligase activator activity. Involved in CXCL12-activated CXCR4 signaling pathway and negative adaptation of signaling pathway. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ENTREP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENTREP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENTREP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:69,035,618–69,036,298 | 289.3 kb | Distal (>10kb) Multiome | 819 | |
| chr9:69,120,411–69,122,618 | 203.3 kb | Distal (>10kb) Multiome | 809 | |
| chr9:69,173,641–69,174,717 | 151.1 kb | Distal (>10kb) Multiome | 542 | |
| chr9:69,324,469–69,325,896 | 334 bp | At TSS Multiome | 399 | |
| chr9:69,409,753–69,410,516 | 84.9 kb | Distal (>10kb) Multiome | 93 | |
| chr9:69,412,310–69,413,137 | 87.6 kb | Distal (>10kb) Multiome | 218 | |
| chr9:69,499,475–69,500,865 | 174.8 kb | Distal (>10kb) Multiome | 110 |
Genomic view of the ENTREP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.