This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for ENTPD7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENTPD7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENTPD7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:99,370,159–99,370,697 | 289.1 kb | Distal (>10kb) Multiome | 14 | |
| chr10:99,430,207–99,431,536 | 228.7 kb | Distal (>10kb) Multiome | 882 | |
| chr10:99,519,844–99,520,769 | 139.3 kb | Distal (>10kb) Multiome | 331 | |
| chr10:99,522,567–99,524,013 | 136.2 kb | Distal (>10kb) Multiome | 201 | |
| chr10:99,527,131–99,527,911 | 132.0 kb | Distal (>10kb) Multiome | 89 | |
| chr10:99,532,575–99,533,287 | 126.6 kb | Distal (>10kb) Multiome | 160 | |
| chr10:99,534,863–99,536,063 | 124.1 kb | Distal (>10kb) Multiome | 193 | |
| chr10:99,536,574–99,538,002 | 122.4 kb | Distal (>10kb) Multiome | 279 | |
| chr10:99,619,825–99,621,725 | 38.8 kb | Distal (>10kb) Multiome | 1070 | |
| chr10:99,658,847–99,660,052 | 117 bp | At TSS Multiome | 728 | |
| chr10:99,731,799–99,732,929 | 72.8 kb | Distal (>10kb) Multiome | 941 | |
| chr10:99,913,671–99,914,615 | 254.6 kb | Distal (>10kb) Multiome | 256 |
Genomic view of the ENTPD7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.