Transcription factors with Perturb-seq knockdown data for ENTPD1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENTPD1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENTPD1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:95,655,874–95,657,154 | 251.2 kb | Distal (>10kb) Multiome | 834 | |
| chr10:95,693,285–95,694,389 | 213.8 kb | Distal (>10kb) Multiome | 744 | |
| chr10:95,840,547–95,841,469 | 67.0 kb | Distal (>10kb) Multiome | 21 | |
| chr10:95,907,059–95,908,292 | 4 bp | At TSS Multiome | 823 | |
| chr10:95,920,289–95,921,295 | 12.7 kb | Distal (>10kb) Multiome | 99 | |
| chr10:96,043,065–96,044,649 | 135.6 kb | Distal (>10kb) Multiome | 891 | |
| chr10:96,129,440–96,130,826 | 222.2 kb | Distal (>10kb) Multiome | 1039 |
Genomic view of the ENTPD1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.