Transcription factors with Perturb-seq knockdown data for ENSG00000291246. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291246 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291246, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:47,948,155–47,948,873 | 234.1 kb | Distal (>10kb) Multiome | 161 | |
| chr1:47,983,776–47,984,855 | 198.1 kb | Distal (>10kb) Multiome | 157 | |
| chr1:47,996,187–47,998,080 | 184.8 kb | Distal (>10kb) Multiome | 504 | |
| chr1:48,024,695–48,025,655 | 157.3 kb | Distal (>10kb) Multiome | 216 | |
| chr1:48,051,694–48,052,373 | 130.3 kb | Distal (>10kb) Multiome | 82 | |
| chr1:48,068,111–48,069,002 | 114.0 kb | Distal (>10kb) Multiome | 109 | |
| chr1:48,073,607–48,074,075 | 108.5 kb | Distal (>10kb) Multiome | 90 | |
| chr1:48,208,078–48,209,322 | 26.4 kb | Distal (>10kb) Multiome | 64 | |
| chr1:48,214,255–48,215,241 | 32.1 kb | Distal (>10kb) Multiome | 110 | |
| chr1:48,442,425–48,443,673 | 260.6 kb | Distal (>10kb) Multiome | 216 | |
| chr1:48,471,474–48,472,912 | 289.7 kb | Distal (>10kb) Multiome | 545 |
Genomic view of the ENSG00000291246 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.