Transcription factors with Perturb-seq knockdown data for ENSG00000291201. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291201 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291201, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:118,351,851–118,353,862 | 238.8 kb | Distal (>10kb) Multiome | 619 | |
| chr4:118,585,607–118,585,971 | 5.8 kb | Proximal (<10kb) | 73 | |
| chr4:118,591,329–118,592,247 | 21 bp | At TSS Multiome | 545 | |
| chr4:118,684,929–118,685,940 | 93.6 kb | Distal (>10kb) Multiome | 728 | |
| chr4:118,834,995–118,836,932 | 244.4 kb | Distal (>10kb) Multiome | 861 | |
| chr4:118,850,099–118,850,712 | 258.6 kb | Distal (>10kb) Multiome | 189 | |
| chr4:118,888,513–118,889,224 | 297.1 kb | Distal (>10kb) Multiome | 392 |
Genomic view of the ENSG00000291201 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.